Synthesis, In vitro Antifungal and Antitumour Activity of Some Triorganotin(IV) N,C,N-Chelates

摘要

The in vitro antifungal activity of compounds 1-3 ( { [ ( CH 3 ) 2 NCH 2 ] 2 C 6 H 3 } R 2 SnX ; (where X=Cl, R=n-Bufor 1, X=Br, R=n-Bu for 2 and x= PF 6 , R=n=Bu for 3)) was estimated with the help of a modifiedmicrodilution format of the M27-A guidelines and was compared with in vitro activity of theirdiphenyltin(IV) analogues 4 and 5 (where X=Br, R=Ph for 4 and X= PF 6 , R=Ph for 5), and of drugs currentlyin clinical use (ketoconazole, fluconazole and amphotericin B). It was found that in coordinating solvents themore soluble derivative 2 is less active than the phenyl one (4), and compounds 1 and 3 are even inactive.